3,5-Di-O-(p-toluyl)-2-deoxy-D-ribofuranosyl chloride

Product ID: M0189

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Intermediate for deoxynucleotide synthesis. This reactive anomeric chloride derivative reacts with nucleophilic bases to provide β-D-ribofuranosyl glycosides.

This reactive ribose analog is a widely used synthon for DNA nucleoside analog preparations. This highly pure active sugar is useful for nucleotide analog syntheses, particularly if one is using a base analog and an unnatural nucleotide is required. Ask about bulk quantity availability.

Technical Data
SKU M0189
CAS Number 4330-21-6
Unit Size 1g
Molecular Formula C₂₁H₂₁ClO₅
Molecular Weight 388.83
Soluble In CHCl3
Storage Conditions -20C, Desiccated
Notes Purity: > 95% (alpha anomer)

References and Citations


  • "Oligodeoxynucleotides containing synthetic abasic sites." Takeshita M, Chang CN, Johnson F, Will S, Grollman AP. J Biol. Chem. 262(21): 10171-10179 (1987).

  • Bhar CC. Synth. Proc. Nucl. Acid Chem. 1:521-522 (1968).

  • Hoffer M. Chem. Ber. 93: 2777 (1960).

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