5-Fluorouridine 5'-O-β-D-galactopyranoside

Product ID: M0174



Unit SizePriceQuantity 
5mg
$131.65
  • Buy 5 for $105.31 each and save 21%

Availability: In stock


Description

Analog of 5-fluorouridine (5-FUR) useful for lacZ specific release of 5-FUR in recombinant cells or tissues.

5-Fluorouridine is a potent anti-metabolite, with mode of action by inhibition of thymidylate synthetase or by incorporation into RNA in vivo. This analog of 5-FU contains a galactose conjugated to the active site of action which, upon enzymatic or chemical hydrolysis of the galactoside group, releases the active anti-metabolite for use in cell selection.

Technical Data
SKU M0174
CAS Number 149965-92-4
Unit Size 5mg
Absorption 268nm
Molecular Formula C₁₅H₂₁N₂O₁₁F
Molecular Weight 424.33
Soluble In H2O, DMSO
Storage Conditions -20C, Desiccated
Notes For research purposes only. Not for human or drug use!!

References and Citations

References:

  • Watanabe KA, Matsuda A, Halat MJ, Hollenberg DH, Nisselbaum JS, Fox JJ. (1981)"Nucleosides. 114. 5-O-glucuronides of 5-fluorouridine and 5-fluorocytidine. Masked precursors of anticancer nucleosides."J Med. Chem. 24: 893-897.

  • Kanzawa F., Hoshi A., Kuretani K., (1980), "Differences between 5-fluoro-2'-deoxyuridine and 5-fluorouridine in their cytotoxic effect on growth of murine lymphoma L5178Y cells in in vivo and in vitro systems." European Journal of Cancer 16(8):1087-92.

  • Iapalucci-Espinoza S., Franze-Fernandez M.T., (1982), "Regulation of rRNA synthesis and processing in animal cells. Effect of nucleoside analogues." The Biochemical Journal 202(2):325-32.

  • Abraham, R., Aman, N., von Borstel, R., Darsley, M., Kamireddy, B., Kenten, J., Morris, G., Titmas, R., (1994), "Conjugates of COL-1 monoclonal antibody and b-d-galactosidase can specifically kill tumor cells by generation of 5-fluorouridine from the prodrug b-d-galactosyl-5-fluorouridine." Cell Biophysics 24/25:127-33.

>Show more
>Show less

Click here for Newsletter articles about this product


Technical Support

Question about this product? Ask a Scientist!

We pride ourselves on the high quality of our products and want you to get the best possible results from your assays. If you have any questions about this product or need help optimizing your protocol check out the product FAQs below or ask your own question and one of our expert scientists will get back to you asap:


There are currently no frequently asked questions for this product, click the button above to ask a question