5-Fluorouridine 5'-O-β-D-galactopyranoside

Product ID: M0174

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Analog of 5-fluorouridine (5-FUR) useful for lacZ specific release of 5-FUR in recombinant cells or tissues.

5-Fluorouridine is a potent anti-metabolite, with mode of action by inhibition of thymidylate synthetase or by incorporation into RNA in vivo. This analog of 5-FU contains a galactose conjugated to the active site of action which, upon enzymatic or chemical hydrolysis of the galactoside group, releases the active anti-metabolite for use in cell selection.

Technical Data
SKU M0174
CAS Number 149965-92-4
Unit Size 5mg
Absorption 268nm
Molecular Formula C₁₅H₂₁N₂O₁₁F
Molecular Weight 424.33
Soluble In H2O, DMSO
Storage Conditions -20C, Desiccated
Notes For research purposes only. Not for human or drug use!!

References and Citations


  • Watanabe KA, Matsuda A, Halat MJ, Hollenberg DH, Nisselbaum JS, Fox JJ. (1981)"Nucleosides. 114. 5-O-glucuronides of 5-fluorouridine and 5-fluorocytidine. Masked precursors of anticancer nucleosides."J Med. Chem. 24: 893-897.

  • Kanzawa F., Hoshi A., Kuretani K., (1980), "Differences between 5-fluoro-2'-deoxyuridine and 5-fluorouridine in their cytotoxic effect on growth of murine lymphoma L5178Y cells in in vivo and in vitro systems." European Journal of Cancer 16(8):1087-92.

  • Iapalucci-Espinoza S., Franze-Fernandez M.T., (1982), "Regulation of rRNA synthesis and processing in animal cells. Effect of nucleoside analogues." The Biochemical Journal 202(2):325-32.

  • Abraham, R., Aman, N., von Borstel, R., Darsley, M., Kamireddy, B., Kenten, J., Morris, G., Titmas, R., (1994), "Conjugates of COL-1 monoclonal antibody and b-d-galactosidase can specifically kill tumor cells by generation of 5-fluorouridine from the prodrug b-d-galactosyl-5-fluorouridine." Cell Biophysics 24/25:127-33.

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