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CAS Number: 319426-57-8
Description:
Cleavage product: Upon enzymatic or chemical hydrolysis of the galactoside group, dexamethasone is produced.
Application:
Dexamethasone is a useful inducer of gene expression when combined with a dexamethasone-inducible promoter system, and is also a potent glucocorticoid anti-inflammatory. Dexamethasone has also been used as an inducer of apoptosis in tumor cells.
View Technical Information ▼
Molecular Weight: 554.6
Storage: F, D
[C=Cold D=Desiccated F=Frozen L=Light Sensitive RT=Room Temperature]
Soluble: DMSO, H2O
Absorption: (in nm) 239
Molecular Formula: C28H39FO10
References:
View References ▼
Pang D., Kocherginsky M., Krausz T., Kim S.Y., Conzen S.D., (2006) "Dexamethasone decreases xenograft response to Paclitaxel through inhibition of tumor cell apoptosis." Cancer Biol. Ther. 5(8): 933-40.
Kim Y.H., Jun J.H., Woo K.M., Ryoo H.M., Kim G.S., Baek J.H., (2006) "Dexamethasone inhibits the formation of multinucleated osteoclasts via down-regulation of beta3 integrin expression." Archives of pharm. research. (Arch Pharm Res) Aug; 29(8): 691-8.
Chauhan D., Li G., Podar K., Hideshima T., Neri P., He D., Mitsiades N., Richardson P., Chang Y., Schindler J., Carver B., Anderson K.C., (2005) "A novel carbohydrate-based therapeutic GCS-100 overcomes bortezomib resistance and enhances dexamethasone-induced apoptosis in multiple myeloma cells." Cancer research. 65(18): 8350-8.
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