Molecular Weight: 77000

CAS Number: [N/A]

Alternative Name: P1 Blood Group Antigen-Bacterial Receptor, Carboxyethylthioethyl 4-O-alpha-D-Galactopyranosyl-beta-D-Galactopyranoside-Bovine serum Albumin Conjugate

Unit Price (USD): 1 mg $229.24

Bulk Price/unit (when you buy 5 or more): $183.39

Description:
This disaccharide represents a portion of the P1 blood group antigen that is responsible for Escherichia coli adhesion to surface membranes of the intestinal tract. Bound to Bovine Serum Albumin (BSA), it is a useful antigen for immunological studies or as an inhibitor of adhesion of endothelial cell binding to uropathogenic E. coli strains.

Note:
D.O.S: 21/BSA

Application:
Synthetic E. coli. receptor.

References:

• "P1-antigen-containing avian egg whites as inhibitors of P adhesins among wild-type Escherichia coli strains from patients with urosepsis." Johnson JR, Ross AE. Infect. Immun. 61(11): 4902-5 (1993).

• "Synthesis of the trisaccharide, 2-(p-trifluoroacetamidophenyl)ethyl O-alpha-D-galactopyranosyl-(1-4)-O-beta-D-galactopyranosyl-(1-4)-2-acet amido-2-deoxy-beta-D-glucopyranoside, corresponding to the blood group P1 determinant." Nilsson S, L¨onn H, Norberg T. Glycoconj. J. 8(1): 9-15 (1991).

• "Specificity of binding of a strain of uropathogenic Escherichia coli to Gal alpha 1----4Gal-containing glycosphingolipids." Bock K, Breimer ME, Brignole A, Hansson GC, Karlsson KA, Larson G, Leffler H, Samuelsson BE, Stromberg N, Eden CS. J Biol. Chem. 260(14): 8545-8551 (1985)

• "Synthesis of spacer-arm, lipid, and ethyl glycosides of the terminal trisaccharide [alpha-D-Gal-(1----4)-beta-D-Gal-(1----4)-beta-D-GlcNAc] portion of the blood-group P1 antigen: preparation of neoglycoproteins." Dahmen J, Frejd T, Magnusson G, Noori G, Carlstrom AS. Carbo. Res. 129: 63-71 (1984).

• "Inhibition of experimental ascending urinary tract infection by an epithelial cell-surface receptor analogue." Eden CS, Freter R, Hagberg L, Hull R, Hull S, Leffler H, Schoolnik G. Nature 298(5874): 560-562 (1982).

• "Glycosphingolipids of human urinary tract epithelial cells as possible receptors for adhering Escherichia coli bacteria." Leffler H, Eden CS. Scand. J. Infect. Dis. Suppl. 24: 144-147 (1980).