Molecular Weight: 424.33
Storage: F, D
[C=Cold D=Desiccated F=Frozen L=Light Sensitive RT=Room Temperature]
Soluble: H2O, DMSO
Absorption: (in nm) 268
Molecular Formula: C15H21N2O11F
CAS Number: [149965-92-4]
Unit Price (USD):
5 mg $101.86
Bulk Price/unit (when you buy 5 or more): $81.49
Description:
Analog of 5-fluorouridine (5-FUR) useful for lacZ specific release of 5-FUR in recombinant cells or tissues.
Note:
For research purposes only. Not for human or drug use!!
Application:
5-FUR is a potent anti-metabolite, with mode of action by inhibition of thymidylate synthetase or by incorporation into RNA in vivo.
References:
Watanabe KA, Matsuda A, Halat MJ, Hollenberg DH, Nisselbaum JS, Fox JJ. (1981)"Nucleosides. 114. 5-O-glucuronides of 5-fluorouridine and 5-fluorocytidine. Masked precursors of anticancer nucleosides."J Med. Chem. 24: 893-897.
Kanzawa F., Hoshi A., Kuretani K., (1980), "Differences between 5-fluoro-2'-deoxyuridine and 5-fluorouridine in their cytotoxic effect on growth of murine lymphoma L5178Y cells in in vivo and in vitro systems." European Journal of Cancer 16(8):1087-92.
Iapalucci-Espinoza S., Franze-Fernandez M.T., (1982), "Regulation of rRNA synthesis and processing in animal cells. Effect of nucleoside analogues." The Biochemical Journal 202(2):325-32.
Abraham, R., Aman, N., von Borstel, R., Darsley, M., Kamireddy, B., Kenten, J., Morris, G., Titmas, R., (1994), "Conjugates of COL-1 monoclonal antibody and b-d-galactosidase can specifically kill tumor cells by generation of 5-fluorouridine from the prodrug b-d-galactosyl-5-fluorouridine." Cell Biophysics 24/25:127-33.
Keywords:
Fluorouridine, 5-O-β-D-Galactopyranoside, 5-O-B-D-Galactopyranoside, 5-O-Beta-D-Galactopyranoside, 5'-O-β-D-Galactopyranoside, 5'-O-B-D-Galactopyranoside, 5'-O-Beta-D-Galactopyranoside, Marker Gene
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