Molecular Weight: 388.83

Storage: F, D

[C=Cold D=Desiccated F=Frozen L=Light Sensitive RT=Room Temperature]

Soluble: CHCl₃

Molecular Formula: C₁₂H₂₁ClO₅

CAS Number: [4330-21-6]

Unit Price (USD): 1 g $361.75

Bulk Price/unit (when you buy 5 or more): $289.40

Description:
Intermediate for deoxynucleotide synthesis. This reactive anomeric chloride derivative reacts with nucleophilic bases to provide β-D-ribofuranosyl glycosides.

Note:
Purity: > 95% (alpha anomer)

Application:
Widely used synthon for DNA nucleoside analog preparations. This highly pure active sugar is useful for nucleotide analog syntheses, particularly if one is using a base analog and an unnatural nucleotide is required. (High purity grade 99+%)

References:

• "Oligodeoxynucleotides containing synthetic abasic sites." Takeshita M, Chang CN, Johnson F, Will S, Grollman AP. J Biol. Chem. 262(21): 10171-10179 (1987).

• Bhar CC. Synth. Proc. Nucl. Acid Chem. 1:521-522 (1968).

• Hoffer M. Chem. Ber. 93: 2777 (1960).