Product M0239
N-(NBD-Aminohexanoyl) Sphingosine


N-(NBD-Aminohexanoyl) Sphingosine

Molecular Weight: 575.75

Storage: F, D

Absorption: (in nm) 460

Emission: (in nm) 534

Molecular Formula: C30H49N5O6

CAS Number: [86701-10-2]

Unit Price (USD): 1 mg $146.00

Bulk Price/unit (when you buy 5 or more): $116.80

Description:
A variety of lysosomal storage diseases as well as intracellular distribution and transport of the labeled sphingolipid molecules in living cells can be detected at the cellular level using this NBD-ceramide analog. Ceramides are the biological building blocks of more complex sphingolipids. Metabolism of ceramides typically occurs in Golgi and endoplasmic reticulum membranes.

References:

  • "Molecular cloning and functional analysis of apoxin I, a snake venom-derived apoptosis-inducing factor with L-amino acid oxidase activity." Torii S, Yamane K, Mashima T, Haga N, Yamamoto K, Fox JW, Naito M, Tsuruo T. Biochemistry 39(12): 3197-3205 (2000).
  • "Selective accumulation of the endoplasmic reticulum-golgi intermediate compartment induced by the antitumor drug KRN5500." Kamishohara M, Kenney S, Domergue R, Vistica DT, Sausville EA. Exp. Cell Res. 256(2): 468-479 (2000).
  • "Involvement of sphingosine in mitochondria-dependent Fas-induced apoptosis of type II jurkat T cells." Cuvillier O, Edsall L, Spiegel S. J Biol. Chem. 275: 15691 (2000).
  • "Defining lipid transport pathways in animal cells." Pagano RE, Sleight RG. Science 229: 1051 (1985).
  • "A vital stain for the golgi apparatus." Lipsky NG, Pagano RE. Science 228: 745 (1985).
  • "Intracellular translocation of fluorescent sphingolipids in cultured fibroblasts: endogenously synthesized sphingomyelin and glucocerebroside analogues pass through the golgi apparatus en route to the plasma membrane." Lipsky NG, Pagano RE. J Cell Biol. 100: 27 (1985).
  • "Intracellular processing of lipids: a theory based on studies with fluorescent lipids, liposomes, and cells." Pagano RE. Liposome Letters, A.D. Bangham, Ed., pp. 83-96 (1983).



Keywords:

N-(NBD-Aminohexanoyl) Sphingosine, NBD-Aminohexanoyl, Sphingosine, Aminohexanoyl, Marker Gene