Molecular Weight: 1057.74
Storage: F, D
[C=Cold D=Desiccated F=Frozen L=Light Sensitive RT=Room Temperature]
Soluble: CH2Cl2, DMSO
Absorption: (in nm) 313
Molecular Formula: C24H8Cl4I4O7
CAS Number: [61738-01-0]
Unit Price (USD):
5 mg $91.14
Bulk Price/unit (when you buy 5 or more): $72.91
Description:
Rose bengal is a per-halogenated fluorescein derivative that is among the most efficient producers of singlet oxygen known. This diacetate derivative exhibits greatly improved membrane permeability, allowing it to accumulate intracellularly where esterase activity releases the active rose bengal photosensitizer.
Note:
Upon esterase activation Rose Bengal Product M1277 is released with ABS= 561 nm
Application:
Activation with UV light at 561 nm causes singlet oxygen production and photosensitization. Rose bengal has been widely used in photodynamic therapy of tumors, to inactivate viruses, gram-positive bacteria and protozoa, and to produce photohemolysis, and induce occlusion of blood vessels in a procedure called photothrombosis.
References:
Bottiroli, G., Croce, A.C., Balzarini, P., Locatelli, D., Baglioni, P., Lo Nostro, P., Monici, M., Pratesi, R.,"Enzyme-assisted cell photosensitization: a proposal for an efficient approach to tumor therapy and diagnosis. The rose bengal fluorogenic substrate." (1997) Photochem. Photobiol. 66, 374-383. Lenard, J., Rabson, A., Vanderoef, R., "Photodynamic inactivation of infectivity of human immunodeficiency virus and other enveloped viruses using hypericin and rose bengal: inhibition of fusion and syncytia formation." (1993) Proc. Natl. Acad. Sci. USA 90:158-162.Dahl, T.A., Midden, W.R., Neckers, D.C., "Comparison of photodynamic action by rose bengal in gram-positive and gram-negative bacteria." (1988) Photochem. Photobiol. 48:607-612.Valenzeno, D.P., Trudgen, J., Hutzenbuhler, A., Milne, M., "Singlet Oxygen involvement in photohemolysis sensitized by mercyanine-540 and rose bengal." (1987) Photochem. Photobiol. 46:985-990.
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