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CAS Number: 61738-01-0
Description:
This diacetate derivative of rose bengal exhibits greatly improved membrane permeability, allowing it to accumulate intracellularly where esterase activity releases the active rose bengal photosensitizer.
Application:
Activation with UV light at 561 nm causes singlet oxygen production and photosensitization. Rose bengal has been widely used in photodynamic therapy of tumors, to inactivate viruses, gram-positive bacteria and protozoa, and to produce photohemolysis, and induce occlusion of blood vessels in a procedure called photothrombosis. Note:
Upon esterase activation Rose Bengal Product M1277 is released with ABS= 561 nm
View Technical Information ▼
Molecular Weight: 1057.74
Storage: F, D
[C=Cold D=Desiccated F=Frozen L=Light Sensitive RT=Room Temperature]
Soluble: CH2Cl2, DMSO
Absorption: (in nm) 313
Molecular Formula: C24H8Cl4I4O7
References:
View References ▼
Bottiroli, G., Croce, A.C., Balzarini, P., Locatelli, D., Baglioni, P., Lo Nostro, P., Monici, M., Pratesi, R.,"Enzyme-assisted cell photosensitization: a proposal for an efficient approach to tumor therapy and diagnosis. The rose bengal fluorogenic substrate." (1997) Photochem. Photobiol. 66, 374-383. Lenard, J., Rabson, A., Vanderoef, R., "Photodynamic inactivation of infectivity of human immunodeficiency virus and other enveloped viruses using hypericin and rose bengal: inhibition of fusion and syncytia formation." (1993) Proc. Natl. Acad. Sci. USA 90:158-162.Dahl, T.A., Midden, W.R., Neckers, D.C., "Comparison of photodynamic action by rose bengal in gram-positive and gram-negative bacteria." (1988) Photochem. Photobiol. 48:607-612.Valenzeno, D.P., Trudgen, J., Hutzenbuhler, A., Milne, M., "Singlet Oxygen involvement in photohemolysis sensitized by mercyanine-540 and rose bengal." (1987) Photochem. Photobiol. 46:985-990.
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Unit Price (USD):
5 mg $95.70
Bulk Price/unit
(5 or more): $76.56
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