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CAS Number: 61738-01-0
This diacetate derivative of rose bengal exhibits greatly improved membrane permeability, allowing it to accumulate intracellularly where esterase activity releases the active rose bengal photosensitizer.
Activation with UV light at 561 nm causes singlet oxygen production and photosensitization. Rose bengal has been widely used in photodynamic therapy of tumors, to inactivate viruses, gram-positive bacteria and protozoa, and to produce photohemolysis, and induce occlusion of blood vessels in a procedure called photothrombosis.
Upon esterase activation Rose Bengal Product M1277 is released with ABS= 561 nm
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Bottiroli, G., Croce, A.C., Balzarini, P., Locatelli, D., Baglioni, P., Lo Nostro, P., Monici, M., Pratesi, R.,"Enzyme-assisted cell photosensitization: a proposal for an efficient approach to tumor therapy and diagnosis. The rose bengal fluorogenic substrate." (1997) Photochem. Photobiol. 66, 374-383. Lenard, J., Rabson, A., Vanderoef, R., "Photodynamic inactivation of infectivity of human immunodeficiency virus and other enveloped viruses using hypericin and rose bengal: inhibition of fusion and syncytia formation." (1993) Proc. Natl. Acad. Sci. USA 90:158-162.Dahl, T.A., Midden, W.R., Neckers, D.C., "Comparison of photodynamic action by rose bengal in gram-positive and gram-negative bacteria." (1988) Photochem. Photobiol. 48:607-612.Valenzeno, D.P., Trudgen, J., Hutzenbuhler, A., Milne, M., "Singlet Oxygen involvement in photohemolysis sensitized by mercyanine-540 and rose bengal." (1987) Photochem. Photobiol. 46:985-990.
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