Molecular Weight: 366.4
Storage: F, D
[C=Cold D=Desiccated F=Frozen L=Light Sensitive RT=Room Temperature]
Soluble: DMF, DMSO
Absorption: (in nm) 450
Extinction (103): 32
Molecular Formula: C19H18O4N4
CAS Number: [146998-31-4]
Unit Price (USD):
25 mg $31.79
Bulk Price/unit (when you buy 5 or more): $25.43
Description:
Long wavelength azo quencher is a useful reagent (similar to MANCYL-SE) for labeling proteins or peptides through their amino-groups. The succinimidyl ester is reactive with terminal amines or lysines of peptides and other nucleophiles for labeling studies of proteins.
Application:
DABCYL has absorption wavelengths that overlap well with EDANS, and some other fluorophores, in FRET-type quenched substrates.
References:
"Synthesis of dye-labeled lysine derivatives." Shen Z, Zhang Y. Synthetic Commun. 30: 2525 (2000)."Synthesis of a fluorogenic interleukin-1 beta converting enzyme substrate based on resonance energy transfer." Pennington MW, Thornberry NA. Pept Res. 7: 72-76 (1994)."Automated synthesis of fluorogenic protease substrates: design of probes for alzheimers disease-associated proteases." Wang GT, Krafft GA. Bioorg Med Chem Lett. 2: 1665 (1992)."A general method for the preparation of internally quenched fluorogenic protease substrates using solid-phase peptide synthesis." Maggiora LL, Smith CW, Zhang ZY. J Med. Chem. 35: 3727-3730 1992).
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