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CAS Number: 531-59-9
Description:
Fluorogenic Cytochrome P450 and microsomal dealkylase substrate for several isoforms of these enzymes with blue fluorescence emission.
Application:
7-hydroxycoumarin M1280 is produced as a result of enzymatic activity. Note:
High Purity (99+%)
View Technical Information ▼
Molecular Weight: 176.17
Storage: RT, L
[C=Cold D=Desiccated F=Frozen L=Light Sensitive RT=Room Temperature]
Soluble: DMSO, MeOH(sl), DMF, CH3CN
Absorption: (in nm) 350
Emission: (in nm) 389
Molecular Formula: C10H8O3
References:
View References ▼
Celik, A., Roberts, G.A., White, J.H., Chapman, S.K., Turner N.J., Flitsch S.L., (2006) "Probing the substrate specificity of the catalytically self-sufficient cytochrome P450 RhF from a Rhodococcus sp." Chem. Commun., 4492-4494.
Kim, K.H., Isin, E.M., Yun, C.H., Kim, D.H., Guengerich, F.P. (2006) "Kinetic deuterium isotope effects for 7-alkoxycoumarin O-dealkylation reactions catalyzed by human cytochromes P450 and in liver microsomes. Rate-limiting C-H bond breaking in cytochrome P450 1A2 substrate oxidation." FEBS Journal 273(10): 2223-2231. Matsubara, T., Yamada, N., Mitomi, T., Yokoyama, S., Fukiishi, Y., Hasegawa, Y., Nishimura, H., (1986) "Cytochrome P-450-dependent monooxygenase activities in prenatal and postnatal human livers: comparison of human liver 7-alkoxycoumarin O-dealkylases with rat liver enzymes. Japanese Journal of Pharmacology 40(3): 389-98. Lindahl, S. R., Scheline, R. R. (1971), "Metabolism of umbelliferone and herniarin in rats and by the rat intestinal microflora." Xenobiotica 1(1): 13-24. Fleck, H. R., Holness, R. F. G., Ward, A. M. (1935) "Some examples of fluorescent acidimetric and adsorption indicators." Analyst 60: 32-3.Warren M., Fry J.R., (1988), "Influence of medium composition on 7-alkoxycoumarin O-dealkylase activities of rat hepatocytes in primary maintenance culture." Xenobiotica 18(8): 973-81. Muthuramu, K., Ramamurthy, V., (1984) "7-Alkoxycoumarins as fluorescence probes for microenvironments." Journal of Photochemistry 26(1): 57-64.
Alternative Name: Methyl umbelliferyl ether, Herniarin
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Unit Price (USD):
50 mg $64.53
Bulk Price/unit
(5 or more): $51.62
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