| || ||
CAS Number: 3520-43-2
This widely used carbocyanine dye is useful as a ratiometric indicator of mitochondrial potential in cells, tissues, and isolated mitochondria.
Upon mitochondrial depolarization JC-1 exhibits a potential-sensitive color shift from red to green, due to concentration-dependent monomerization of red fluorescent J-aggregates. It has been used to detect the collapse of mitochondrial membrane potential in functional assays of multiple drug resistance and in apoptosis-related mitochondrial membrane potential measurements.
View Technical Information ▼
View References ▼
Reers M, Smith TW, Chen LB(1991)
"J-aggregate formation of a carbocyanine as a quantitative fluorescent indicator of membrane potential." Biochemistry 30(18):4480-4486.
Shapiro HM (1994)"Cell membrane potential analysis." Methods Cell Biol. 41:121-133.
Bedner E, Li X, Gorczyca W, Melamed MR, Darzynkiewicz Z (1999)"Analysis of apoptosis by laser scanning cytometry." Cytometry 35(3):181-195.
Alternative Name: 5,5',6,6'-Tetrachloro-1,1',3,3'-tetraethylbenzimidazolylcarbocyanine Iodide
Unit Price (USD):
5 mg $226.00
(5 or more):