M1842 - JC-1

(5,5',6,6'-Tetrachloro-1,1',3,3'-tetraethylbenzimidazolylcarbocyanine Iodide)

CAS Number: 3520-43-2

Description:
This widely used carbocyanine dye is useful as a ratiometric indicator of mitochondrial potential in cells, tissues, and isolated mitochondria.

Application:
Upon mitochondrial depolarization JC-1 exhibits a potential-sensitive color shift from red to green, due to concentration-dependent monomerization of red fluorescent J-aggregates. It has been used to detect the collapse of mitochondrial membrane potential in functional assays of multiple drug resistance and in apoptosis-related mitochondrial membrane potential measurements.

References:
View References ▼