6-Amino-D-luciferin

Product ID: M0352



Unit SizePriceQuantity 
5mg
$164.65
  • Buy 5 for $131.71 each and save 21%

Availability: In stock


Description

Amino analog of the D-luciferin substrate for measuring firefly luciferase activity.

Amino analog of the common D-luciferin substrate for use in measuring firefly luciferase activity. Use this cell permeable reagent when considering design of proluminescent bioconjugates (peptidase substrates) of luciferin for ultrasensitive luminescent assays.

Technical Data
SKU M0352
CAS Number 161055-47-6
Unit Size 5mg
Alternative Names 4,5-dihydro-2[6-amino-2-benzthiazolyl]-4-thiazole carboxylic acid
Detection Method Luminescence
Molecular Formula C₁₁H₉N₃O₂S₂
Molecular Weight 279.34
Storage Conditions -20C, Desiccated

References and Citations

Citations:

  • Mofford DM, Reddy GR, Miller SC. (2014) "Latent luciferase activity in the fruit fly revealed by a synthetic luciferin." Proceedings of the National Academy of Sciences of the United States of America. 111(12):4443-4448.
  • Harwood KR, Mofford DM, Reddy GR, Miller SC. (2011) "Identification of mutant firefly luciferases that efficiently utilize aminoluciferins." Chem Biol. 18(12):1649-57.
  • Chandran SS, Williams SA, Denmeade SR. (2009) "Extended-release PEG-luciferin allows for long-term imaging of firefly luciferase activity in vivo." Luminescence. 24(1):35-8.
  • Jathoul A, Law E, Gandelman O, Pule M, Tisi L, Murray J (2012). "Development of a pH-Tolerant Thermostable Photinus pyralis Luciferase for Brighter In Vivo Imaging, Bioluminescence" Recent Advances in Oceanic Measurements and Laboratory Applications, Chapter 6, ISBN: 978-953-307-940-0.
  • Shinde R, Perkins J, Contag CH. (2006) “Luciferin derivatives for enhanced in vitro and in vivo bioluminescence assays.” Biochemistry 45: 11103-11112.
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References:

  • White EH, Woerther H, Seliger HH, McElroy WD. (1966) "Amino analogs of firefly luciferin and biological activity thereof." J Amer Chem Soc 88(9): 2015-18.
  • Denburg J, Lee RT, McElroy W D. (1969), "Substrate-binding properties of firefly luciferase. I. Luciferin-binding site." Arch Biochem Biophys 134(2): 381-94.
  • O'Brien MA, Daily WJ, Hesselberth PE, Moravec RA, Scurria MA, Klaubert DH, Bulleit RF, Wood KV. (2005) "Homogeneous, bioluminescent protease assays: Caspase-3 as a model." J Biomolec Screening 10(2): 137-148.
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