Berberine sulfate

Product ID: M1257



Unit SizePriceQuantity 
25mg
$80.28
  • Buy 5 for $64.22 each and save 21%

Availability: In stock


Description

Useful as a fluorescent stain for heparin in several mammalian cell lines.

An effector for MDR (multidrug resistance)efflux pumps and is potentiated by the MDR inhibitor 5'-methoxyhydnocarpin (5'-MHC). Treatment with berberine potentially results in the reduced accumulation of chemotherapeutic drugs. Berberine upregulates the expression of Pgp in hepatoma cells.

Technical Data
SKU M1257
CAS Number 316-41-6
Unit Size 25mg
Alternative Names berberine sulfate hydrate
Detection Method Fluorescence
Molecular Formula C₄₀H₃₆N₂O₁₂S x H₂O
Molecular Weight 768.79

References and Citations

References:

  • Stermitz, F.R., (2000) "Synergy in a medicinal plant: Antimicrobial action of berberine potentiated by 5'-methoxyhydnocarpin, a multidrug pump inhibitor." Proc. Natl. Acad. Sci. USA 97, 1433.
  • Berlin, G., Enerback, L. (1984) "Non-differential inhibition of histamine and serotonin release from mast cells by amitriptyline." Agents and Actions 14: 401.
  • Lin, H.L. (1999) "Up-regulation of multidrug resistance transporter expression by berberine in human and murine hepatoma cells." Cancer 85: 1937-1942.
  • Schumacher, M.A., Miller, MC, Grkovic, S, Brown, MH, Skurray, RA, Brennan RG, (2001) "Structural Mechanisms of QacR Induction and Multidrug Recognition." Science 294: 2158-2163.
  • Enerback L. (1974) "Berberine sulphate binding to mast cell polyanions: A cytofluorometric method for the quantitation of heparin." Histochemistry 42: 301–313.
  • Dimlich RV, Meineke HA, Reilly FD, McCuskey RS (1980) "The fluorescent staining of heparin in mast cells using berberine sulfate: compatibility with paraformaldehyde or o-phthalaldehyde induced fluorescence and metachromasia." Stain Technol. 55(4):217-23.
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