Biocytin

Product ID: M4275



Unit SizePriceQuantity 
100mg
$66.00

Availability: Out of stock


Description

A versatile marker used in neuroanatomical investigations and biotinidase assays. Has been shown to transport and recycle biotin in vivo.

Biocytin is a Chromogenic, fixable with aldehyde-based fixatives, transneuronal tracer Molecule which is covelantly biotinylated with amino acid (L-Lysine) and it can be introduced into cells by microinjection. The primary amine on the lysine can be coupled to aldehydes/ketones to form a Schiff base – which can be reduced with sodium borohydride (NaBH4) or sodium cyanoborohydride (NaCNH3) to form a stable drivative. Carboxylic acids of proteins and other water-soluble molecules can be coupled to this molecule in aqueous solution using water-soluble carbodiimides such as EDAC

Technical Data
SKU M4275
CAS Number 576-19-2
Unit Size 100mg
Alternative Names ε-Biotinoyl-L-lysine
Molecular Formula C16H28N4O4S
Molecular Weight 372.5
Soluble In DMSO, DMF, Chloroform
Storage Conditions -20C, protect from light, dessicate

References and Citations

References:

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  • Wilson RI, Turner GC, Laurent G. (2004) ""Transformation of olfactory representations in the Drosophila antennal lobe."" Science 303, 366-70
  • Ladd PA, Du L, Capdevila JH, Mernaugh R, Keeney DS. (2003) ""Epoxyeicosatrienoic acids activate transglutaminases in situ and induce cornification of epidermal keratinocytes."" J Biol Chem 278, 35184-92
  • Pawelzik H, Hughes DI, Thomson AM. (2002) ""Physiological and morphological diversity of immunocytochemically defined parvalbumin- and cholecystokinin-positive interneurones in CA1 of the adult rat hippocampus."" J Comp Neurol 443, 346-367
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