C12-NBD, free acid (12-(7-Nitrobenzofurazan-4-ylamino)dodecanoic acid)

Product ID: M1080

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Useful fluorescent probe for fatty acid and carrier protein binding sites.

This fluorescent fatty acid analog contains the lipid fluorophore NBD. It can be reacted with amino containing biological compounds to produce derivatives such as C12-NBD ceramide or C12-NBD cholesterol, This environment sensitive, fluorescent fatty acid analog is also useful in bioconjugation to other lipids or proteins.

Technical Data
SKU M1080
CAS Number 96801-39-7
Unit Size 100mg
Alternative Names 12-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)dodecanoic acid; NBD-aminododecanoic acid
Absorption 466nm
Emission Wavelength 530
Extinction 24
Detection Method Fluorescence
Molecular Formula C₁₈H₂₆N₄O₅
Molecular Weight 378.43
Soluble In DMF, DMSO, MeOH
Storage Conditions -20C, Protect From Light

References and Citations


  • "Purification and characterization of a neutral ceramidase from mouse liver. A single protein catalyzes the reversible reaction in which ceramide is both hydrolyzed and synthesized." Tani M, Okino N, Mitsutake S, Tanigawa T, Izu H, Ito M. J Biol Chem 275: 3462-3468 (2000).
  • "Probing the ligand binding sites of fatty acid and sterol carrier proteins: effects of ethanol." Schroeder F, Myers-Payne SC, Billheimer JT, Wood WG. Biochemistry 34(37): 11919-27 (1995).
  • "Lateral diffusion of lipids in model and natural membranes." Tocanne JF, Dupou-Cezanne L, Lopez A. Prog Lipid Res 33: 203-237 (1994).
  • "Large-scale preparation of asymmetrically labeled fluorescent lipid vesicles." Dao HN, McIntyre JC, Sleight RG. Anal Biochem 196: 46-53 (1991).
  • "Human acid beta-glucosidase: use of inhibitors, alternative substrates and amphiphiles to investigate the properties of the normal and Gaucher disease active sites." Osiecki-Newman K, Fabbro D, Legler G, Desnick RJ, Grabowski GA. Biochim Biophys Acta 15: 87-100 (1987).
  • "Prenatal diagnosis of Krabbe disease using a fluorescent derivative of galactosylceramide." Zeigler M, Zlotogora J, Regev R, Dagan A, Gatt S, Bach G. Clin Chim Acta 142: 313-318 (1984).
  • "Gaucher type I (Ashkenazi) disease: a new method for heterozygote detection using a novel fluorescent natural substrate." Grabowski GA, Dinur T, Gatt S, Desnick RJ. Clin Chim Acta 124: 123-135 (1982).
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