4-[4-(Dimethylamino)phenylazo]benzoic acid, N-succinimidyl ester

Product ID: M1051

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Long wavelength azo quencher is a useful reagent (similar to MANCYL-SE) for labeling proteins or peptides through their amino-groups. The succinimidyl ester is reactive with terminal amines or lysines of peptides and other nucleophiles for labeling studies of proteins.

DABCYL is a widely use azo quencher that has absorption wavelengths that overlap well with EDANS, and some other fluorophores, in FRET-type quenched substrates. This reactive version of DABCYL has an NHS (N-hydroxysuccinimidyl) group that allows easy labeling of proteins or peptides for use in substrates or other detection systems.

Technical Data
SKU M1051
CAS Number 146998-31-4
Unit Size 25mg
Absorption 450nm
Extinction 32
Molecular Formula C₁₉H₁₈O₄N₄
Molecular Weight 366.4
Soluble In DMF, DMSO
Storage Conditions -20C, Desiccated

References and Citations


  • "Synthesis of dye-labeled lysine derivatives." Shen Z, Zhang Y. Synthetic Commun. 30: 2525 (2000).
  • "Synthesis of a fluorogenic interleukin-1 beta converting enzyme substrate based on resonance energy transfer." Pennington MW, Thornberry NA. Pept Res. 7: 72-76 (1994).
  • "Automated synthesis of fluorogenic protease substrates: design of probes for alzheimers disease-associated proteases." Wang GT, Krafft GA. Bioorg Med Chem Lett. 2: 1665 (1992).
  • "A general method for the preparation of internally quenched fluorogenic protease substrates using solid-phase peptide synthesis." Maggiora LL, Smith CW, Zhang ZY. J Med. Chem. 35: 3727-3730 1992).
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