DiR (1,1'-Dioctadecyl-3,3,3',3'-tetramethylindotricarbocyanine iodide)

Product ID: M1577

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  • Buy 5 for $76.52 each and save 21%

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Lipophilic near-IR (NIR) fluorescent membrane probe useful for labeling cells for long term analysis.

This tricarbocyanine fluorophore is excited at 750 nm and has an emission peak at 782 nm. It also has virtually no fluorescence in water, while having high fluorescence when incorporated into cell membranes. Long-chain dialkylcarbocyanines are widely used as anterograde and retrograde neuronal tracers in living and fixed tissues and cells.

Technical Data
SKU M1577
CAS Number 100068-60-8
Unit Size 25mg
Absorption 750nm
Emission Wavelength 782
Detection Method Fluorescence
Molecular Formula C₆₃H₁₀₁N₂I
Molecular Weight 1013.39
Soluble In CH2Cl2, MeOH
Storage Conditions -20C, Protect From Light, Desiccated

References and Citations


  • Kalchenko V, Shivtiel S, Malina V, Lapid K, Haramati S, Lapidot T, Brill A, Harmelina A, (2006) "Use of lipophilic near-infrared dye in whole-body optical imaging of hematopoietic cell homing." J. Biomed. Optics 11(5): 050507-1.
  • Sipkins DA, Wei X, Wu JW, Runnels JM, Cote D, Means TK, Luste AD. Scadden DT, Lin CP, (2005).“In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment,” Nature (London) 435: 969-973.
  • Eisenblätter M, Ehrchen J, Varga G, Sunderkötter C, Heindel W, Roth J, Bremer C, Wall A. (2009) "In vivo optical imaging of cellular inflammatory response in granuloma formation using fluorescence-labeled macrophages." J. Nucl. Med. 50(10):1676-82.
  • Texier I, Goutayer M, Da Silva A, Guyon L, Djaker N, Josserand V, Neumann E, Bibette J, Vinet F (2009) "Cyanine-loaded lipid nanoparticles for improved in vivo fluorescence imaging." J. Biomed. Opt. 14(5):054005.
  • O'Brien JA, Lummis SC (2007) "Dolistics: incorporating fluorescent dyes into biological samples using a gene gun." Trends Biotechnol. 25(11):530-534.
  • de L. Davies C, Lundstrøm, LM, Frengen J, Eikenes L, Bruland OS, Kaalhus O, Hjelstuen MHB, Brekken C (2004) "Radiation Improves the Distribution and Uptake of Liposomal Doxorubicin (Caelyx) in Human Osteosarcoma Xenografts." Cancer Res. 64: 547–553.
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