DiR (1,1'-Dioctadecyl-3,3,3',3'-tetramethylindotricarbocyanine iodide)

Product ID: M1577



Unit SizePriceQuantity 
25mg
$95.65
  • Buy 5 for $76.52 each and save 21%

Availability: In stock


Description

Lipophilic near-IR (NIR) fluorescent membrane probe useful for labeling cells for long term analysis.

This tricarbocyanine fluorophore is excited at 750 nm and has an emission peak at 782 nm. It also has virtually no fluorescence in water, while having high fluorescence when incorporated into cell membranes. Long-chain dialkylcarbocyanines are widely used as anterograde and retrograde neuronal tracers in living and fixed tissues and cells.

Technical Data
SKU M1577
CAS Number 100068-60-8
Unit Size 25mg
Absorption 750nm
Emission Wavelength 782
Detection Method Fluorescence
Molecular Formula C₆₃H₁₀₁N₂I
Molecular Weight 1013.39
Soluble In CH2Cl2, MeOH
Storage Conditions -20C, Protect From Light, Desiccated

References and Citations

References:

  • Kalchenko V, Shivtiel S, Malina V, Lapid K, Haramati S, Lapidot T, Brill A, Harmelina A, (2006) "Use of lipophilic near-infrared dye in whole-body optical imaging of hematopoietic cell homing." J. Biomed. Optics 11(5): 050507-1.
  • Sipkins DA, Wei X, Wu JW, Runnels JM, Cote D, Means TK, Luste AD. Scadden DT, Lin CP, (2005).“In vivo imaging of specialized bone marrow endothelial microdomains for tumour engraftment,” Nature (London) 435: 969-973.
  • Eisenblätter M, Ehrchen J, Varga G, Sunderkötter C, Heindel W, Roth J, Bremer C, Wall A. (2009) "In vivo optical imaging of cellular inflammatory response in granuloma formation using fluorescence-labeled macrophages." J. Nucl. Med. 50(10):1676-82.
  • Texier I, Goutayer M, Da Silva A, Guyon L, Djaker N, Josserand V, Neumann E, Bibette J, Vinet F (2009) "Cyanine-loaded lipid nanoparticles for improved in vivo fluorescence imaging." J. Biomed. Opt. 14(5):054005.
  • O'Brien JA, Lummis SC (2007) "Dolistics: incorporating fluorescent dyes into biological samples using a gene gun." Trends Biotechnol. 25(11):530-534.
  • de L. Davies C, Lundstrøm, LM, Frengen J, Eikenes L, Bruland OS, Kaalhus O, Hjelstuen MHB, Brekken C (2004) "Radiation Improves the Distribution and Uptake of Liposomal Doxorubicin (Caelyx) in Human Osteosarcoma Xenografts." Cancer Res. 64: 547–553.
>Show more
>Show less

Click here for Newsletter articles about this product


Technical Support

Question about this product? Ask a Scientist!

We pride ourselves on the high quality of our products and want you to get the best possible results from your assays. If you have any questions about this product or need help optimizing your protocol check out the product FAQs below or ask your own question and one of our expert scientists will get back to you asap:


There are currently no frequently asked questions for this product, click the button above to ask a question

Recently Viewed Products
  1. FAM-Spacer-Phe-CMK Green FLISP™ Assay Kit - 25tests

    FAM-Spacer-Phe-CMK Green FLISP™ Assay Kit - 25tests