1-[4-(Dimethylamino)phenyl]-6-phenylhexatriene (DMA-DPH)

Product ID: M1088

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Useful fluorescent probe of lipid bilayer structure and dynamics. Used to monitor cell membrane interiors.

Time-resolved fluorescence anisotropy and polarized fluorescence measurements of oriented samples have shown DPH to be mainly oriented parallel to the lipid bilayer axis, but it can also reside in the center of the lipid bilayer parallel to the surface. In order to improve the localization of DPH in the membrane, the polar derivatives DMA-DPH and TMA-DPH M1091 have been developed that contain a cationic trimethylammonium substituent which provides a membrane surface anchor.

Technical Data
SKU M1088
CAS Number 79849-61-9
Unit Size 100mg
Alternative Names DMA-DPH
Emission Wavelength 515
Extinction 57
Detection Method Fluorescence
Molecular Formula C₂₀H₂₁N
Molecular Weight 275.39
Soluble In DMF, MeOH, Acetonitrile
Storage Conditions Room Temperature
Notes Ex: 332nm

References and Citations


  • "Simultaneous double probing of the microenvironment in colloidal systems and molecular assemblies by DPH derivatives." Pistolis G, Malliaris A. Langmuir 13(6): 1457-1462 (1997).
  • "Fluorescence monitoring of polarity change and gelation during epoxy cure." Lin KF, Wang FW. Polymer 35(4): 687-91 (1994).
  • "1-[4-(Trimethylamino)phenyl]-6-phenylhexa-1,3,5-triene:synthesis, fluorescence properties, and use as a fluorescence probe of lipid bilayers." Prendergast FG, Haugland RP, Callahan PJ. Biochemistry 20: 7333-8 (1981).
  • "Photophysical properties of DPH derivatives." Cundall RB, Johnson I, Jones MW, Thomas EW, Munro IH. Chemical Physics Letters 64(37): 39-42 (1979).
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