Hexosaminidase

Absence of hexosaminidase A is the cause of Tay-Sachs disease and similar variants, while total hexosaminidase deficiency (hexosaminidase A and hexosaminidase B) occurs in Sandhoff disease. Two subunits, a and b, coded by genes HEXA and HEXB, comprise the hexosaminidases. Hex A is α and hex B is β. New fluorogenic substrates are emerging to measure levels of hexosamindase/galactosaminidase activity in cell preparations and in vitro.

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  1. Resorufin β-D-N-acetylgalactosamine

    Resorufin β-D-N-acetylgalactosamine

    $98.80

    Useful fluorescent substrate for galactosaminidase or hexosaminidase activity measurements in Tay-Sachs and Sandhoff diseases. The red fluorescent product, resorufin, exhibits emission at 585 nm when excited at 570nm. Learn More
  2. Fluorescein mono-β-D-N-acetylgalactosamine

    Fluorescein mono-β-D-N-acetylgalactosamine

    $98.80

    Useful fluorescent substrate for galactosaminidase or hexosaminidase activity measurements in Tay-Sachs and Sandhoff diseases. Learn More
  3. 2',7'-Dichlorofluorescein

    2',7'-Dichlorofluorescein

    $64.36

    Green fluorophore standard used for labeling and in enzyme assay systems. Learn More
  4. Fluorescein mono-beta-D-N-acetylglucosamine

    Fluorescein mono-beta-D-N-acetylglucosamine

    $98.80

    Fluorogenic substrate for hexosaminidase enzymes. Has been used for enzymatic characterization of O-GlcNAcase isoforms. Learn More

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