Marker Gene Technologies - Enzyme Substrates and Kits for β-Hexosaminidase

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Enzyme Substrates and Kits for β-Hexosaminidase

Absence of hexosaminidase A is the cause of Tay-Sachs disease and similar variants, while total hexosaminidase deficiency (hexosaminidase A and hexosaminidase B) occurs in Sandhoff disease. Two subunits, a and b, coded by genes HEXA and HEXB, comprise the hexosaminidases. Hex A is αβ and hex B is ββ. New fluorogenic substrates are emerging to measure levels of hexosamindase/galactosaminidase activity in cell preparations and in vitro.

  ID   Name   CAS Unit Size Price Bulk Price (5+)

M1037   Resorufin β-D-N-acetylgalactosamine N/A 10 mg 80.27 64.22

Useful fluorescent substrate for galactosaminidase or hexosaminidase activity. The fluorescent product, resorufin, has Abs 570nm / Em 585 nm.

M1485   Fluorescein mono-β-D-N-Acetylglucosamine 148806-95-5 5 mg 80.27 64.22

Fluorogenic substrate for hexosaminidase enzymes. Has been used for enzymatic characterization of O-GlcNAcase isoforms.

M1040   Fluorescein mono-β-D-N-acetylgalactosamine N/A 5 mg 80.27 64.22

Useful fluorescent substrate for galactosaminidase or hexosaminidase activity.

M0308   Fluorescein di-β-D-N-acetylgalactosamine N/A 5 mg 106.95 85.56

Useful ultrasensitive fluorescent substrate for galactosaminidase or hexosaminidase activity.

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