Product ID: M1842

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This widely used carbocyanine dye is useful as a ratiometric indicator of mitochondrial potential in cells, tissues, and isolated mitochondria.

Upon mitochondrial depolarization JC-1 exhibits a potential-sensitive color shift from red to green, due to concentration-dependent monomerization of red fluorescent J-aggregates. It has been used to detect the collapse of mitochondrial membrane potential in functional assays of multiple drug resistance and in apoptosis-related mitochondrial membrane potential measurements.

Technical Data
SKU M1842
CAS Number 3520-43-2
Unit Size 5mg
Alternative Names 5,5',6,6'-Tetrachloro-1,1',3,3'-tetraethylbenzimidazolylcarbocyanine Iodide
Detection Method Fluorescence
Molecular Formula C₂₅H₂₇Cl₄IN₄
Molecular Weight 652.22
Soluble In DMSO
Storage Conditions Room temperature, Desiccated, Protect From Light

References and Citations


  • Reers M, Smith TW, Chen LB(1991) "J-aggregate formation of a carbocyanine as a quantitative fluorescent indicator of membrane potential." Biochemistry 30(18):4480-4486.
  • Shapiro HM (1994)"Cell membrane potential analysis." Methods Cell Biol. 41:121-133.
  • Bedner E, Li X, Gorczyca W, Melamed MR, Darzynkiewicz Z (1999)"Analysis of apoptosis by laser scanning cytometry." Cytometry 35(3):181-195.
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