MarkerGene™ LysoLive™ Lysosomal Acid Lipase Assay Kit

Product ID: M2887



Unit SizePriceQuantity 
1 kit
$420.50

Availability: In stock


Description

This kit utilizes the sensitive substrate LipaGreen™ to monitor acid lipase activity in the lysosomes of live cells by flow cytometry.

The MarkerGene™ LysoLive™ Lysosomal Acid Lipase Assay Kit utilizes a sensitive substrate for lysosomal acid lipase (LAL), an enzyme indicated in several diseases such as Lysosomal Acid Lipase Deficiency (LALD). The substrate only becomes fluorescent upon cleavage by the enzyme meaning lysosomes with low acid lipase activity will have reduced staining in a manner proportional to the enzyme activity levels found in the cell.

Important Licensing Information: This product may be covered by one or more United States or International Patents and is subject to our Limited Use Label Licenses. By use of this product, you accept the terms and conditions of all applicable Limited Use Label Licenses. See product information sheet for more details
Corporate entity: Marker Gene Technologies, Inc., Eugene, Oregon, USA

Technical Data
SKU M2887
Unit Size 1 kit
Detection Method Fluorescence
Storage Conditions -20C, Protect From Light

References and Citations

Citations:

  • Harlan FK, Lusk JS, Mohr BM, Guzikowski AP, Batchelor RH, Jiang Y, et al. (2016) "Fluorogenic Substrates for Visualizing Acidic Organelle Enzyme Activities." PLoS ONE 11(5): e0156312. doi:10.1371/journal.pone.0156312
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References:

  • Gokce S. (2016) “The Key Clinical Manifestations of Lysosomal Acid Lipase Deficiency.” J Pediatr Gastroenterol Nutr. 63(3):e39.
  • Karageorgos LE, Isaac EL, Brooks DA, Ravenscroft EM, Davey R, Hopwood JJ, Meikle PJ. (1997) “Lysosomal biogenesis in lysosomal storage disorders.” Experimental Cell Research 234, 85-97.
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