MarkerGene™ LysoLive™ Lysosomal β-Galactosidase Assay Kit

Product ID: M2776



Unit SizePriceQuantity 
1 kit
$408.43

Availability: In stock


Description

This kit utilizes the sensitive substrate GalGreen™ to monitor beta-galactosidase activity in the lysosomes of live cells.

The MarkerGene™ LysoLive™ Lysosomal beta-Galactosidase Assay Kit utilizes a sensitive substrate for lysosomal beta-galactosidase (GALC), an enzyme indicated in several diseases such as Krabbe disease and Morquio Syndrome. The substrate only becomes fluorescent upon cleavage by the enzyme meaning lysosomes with low beta-Galactosidase activity will have reduced staining in a manner proportional to the enzyme activity levels found in the cell.

Important Licensing Information: This product may be covered by one or more United States or International Patents and is subject to our Limited Use Label Licenses. By use of this product, you accept the terms and conditions of all applicable Limited Use Label Licenses. See product information sheet for more details
Corporate entity: Marker Gene Technologies, Inc., Eugene, Oregon, USA

Technical Data
SKU M2776
Unit Size 1 kit
Detection Method Fluorescence

References and Citations

Citations:

  • Harlan FK, Lusk JS, Mohr BM, Guzikowski AP, Batchelor RH, Jiang Y, et al. (2016) "Fluorogenic Substrates for Visualizing Acidic Organelle Enzyme Activities." PLoS ONE 11(5): e0156312. doi:10.1371/journal.pone.0156312
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References:

  • Suzuki K, Suzuki Y (1970) "Globoid cell leucodystrophy (Krabbe’s disease): Deficiency of Lysosomal Galactocerebroside -galactosidase" Proceedings of the National Academy of Sciences 66(2):302–309.
  • Kolodny EH, Raghavan S, Krivit W. (1991) “Late-onset Krabbe disease (globoid cell leukodystrophy): clinical and biochemical features of 15 cases.” Dev Neurosci. 13(4-5):232-9.
  • Karageorgos LE, Isaac EL, Brooks DA, Ravenscroft EM, Davey R, Hopwood JJ, Meikle PJ (1997) “Lysosomal biogenesis in lysosomal storage disorders.” Experimental Cell Research 234, 85-97.
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