MarkerGene™ Lysosomal Galactocerebrosidase (GALC) Analysis Kit

Product ID: M2774

Unit SizePriceQuantity 
1 kit
  • Buy 5 for $239.11 each and save 20%

Availability: In stock


This kit offers an easy to use protocol for detecting levels of lysosomal galactocerebrosidase in many cells types (adherent or non-adherent).

Krabbe Disease is an autosomal recessive disorder that results from a deficiency in an enzyme known as galactocerebrosidase (galactosylceramidase, GALC). It is also called Globoid Cell Leukodystrophy. This name derives from the characteristic pathology of Krabbe Disease, where macrophages accumulate high levels of undegraded galactolipids as a result of the lack of GALC activity. These cells produce a characteristic morphology difference from healthy cells, and are often termed globoid cells. The MarkerGene™ Lysosomal Galactocerebrosidase Analysis kit offers an easy to use protocol for detecting levels of lysosomal galactocerebrosidase in many cells types (adherent or non-adherent) using a lysate method and a specific lipidic fluorogenic substrate.

Technical Data
SKU M2774
Unit Size 1 kit
Alternative Names GALC Analysis Kit
Detection Method Fluorescence
Storage Conditions See individual vials for storage conditions

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References and Citations


  • Wiederschain G, Srinivasa R, Kolodny E. (1992) "Characterization of 6-hexadecanoylamino-4-methylumbelliferyl-β-d-galactopyranoside as fluorogenic substrate of galactocerebrosidase for the diagnosis of Krabbe disease" Clin Chim Acta 205(1-2):87–96.
  • Svennerholm L, Vanier MT, Håkansson G. (1981) "Use of leukocytes in diagnosis of Krabbe disease and detection of carriers." Clinica Chimica 112 (1981) 333-342.
  • Kolodny E, Mumford R. (1976) "Human leukocyte acid hydrolases: Characterization of eleven lysosomal enzymes and study of reaction conditions for their automated analysis" Clin Chim Acta 70(2):247–257.
  • Suzuki K, Suzuki Y. (1970) "Globoid cell leucodystrophy (Krabbe’s disease): Deficiency of galactocerebroside -galactosidase." Proceedings of the National Academy of Sciences 66(2):302–309.
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