Molecular Weight: 366.4
Storage: F, D
[C=Cold D=Desiccated F=Frozen L=Light Sensitive RT=Room Temperature]
Soluble: DMF, DMSO
Absorption: (in nm) 450
Extinction (103): 32
Molecular Formula: C19H18O4N4
CAS Number: [146998-31-4]
Unit Price (USD):
25 mg $31.79
Bulk Price/unit (when you buy 5 or more): $25.43
Description:
This long wavelength azo quencher is a useful reagent (similar to MANCYL-SE) for labeling proteins or peptides through their amino-groups. The succinimidyl ester is reactive with terminal amines or lysines of peptides and other nucleophiles for labeling studies of proteins. DABCYL has absorption wavelengths that overlap well with EDANS, and some other fluorophores, in FRET-type quenched substrates.
References:
"Synthesis of dye-labeled lysine derivatives." Shen Z, Zhang Y. Synthetic Commun. 30: 2525 (2000)."Synthesis of a fluorogenic interleukin-1 beta converting enzyme substrate based on resonance energy transfer." Pennington MW, Thornberry NA. Pept Res. 7: 72-76 (1994)."Automated synthesis of fluorogenic protease substrates: design of probes for alzheimers disease-associated proteases." Wang GT, Krafft GA. Bioorg Med Chem Lett. 2: 1665 (1992)."A general method for the preparation of internally quenched fluorogenic protease substrates using solid-phase peptide synthesis." Maggiora LL, Smith CW, Zhang ZY. J Med. Chem. 35: 3727-3730 1992).
