RESEARCH
 Let us help you with your project...
Marker Gene Technologies, Inc. has the expertise to perform contract research with you on your project. We have worked with many biotechnology and pharmaceutical companies on successful, patented projects.
- Contract Research and Development Capabilities in the following areas:
- Extensive experience in patent preparation and filings.
- Four fully equipped laboratories (Biochemistry, Synthesis, Tissue Culture, Analytical) with adjacent libraries.
- Enzymological assay development and in vivo analysis.
- Drug design, synthesis, and in vitro testing in human cell culture.
- Enzyme substrate/coupled assay, design, and synthesis.
- Enzyme inhibitor design, synthesis, and inhibition assays.
- In vivo assay development and testing in-house.
- Chromogenic, Chemiluminescent, and Fluorescense Based Technologies.
- New uses for marker genes in vivo (Research, Diagnostics, Therapeutics).
- Specializing in Carbohydrate, Peptide, and Nucleic Acid Chemistries.
- Quick turn-around for initial efficacy trials (usually 90 days or less).
- Joint Government (SBIR) Proposal Collaborations.
- cGMP certified laboratory.
RECENT PUBLICATIONS:
- Jiang Y, Harrington CA, Naleway MA, Strain SM, Savage SL, Slottke RE, Vartanian KA, Naleway JJ (2011) "Toward Unbiased Direct DNA and RNA Labeling Systems." Presented at the American Society for Cell Biology Meeting, Denver, CO, December, 2011 Poster 1157/B608 link
- Harlan FK, Jiang Y, Galvao R, Deligeorgiev T, Naleway JJ (2011) "Cell Biology Assays Using Improved DNA Detection Reagents." Presented at the American Society for Cell Biology Meeting, Denver, CO, December, 2011 Poster 1156/B607. link
- Naleway JJ, Jiang Y, Harlan FK, Deligeorgiev T, Gadje N,
Kaloyanova S, Lesev N, Vasilev A, Timcheva I, Maximov V "The Homodimeric Nucleic Acid Dyes 6-ChloroYOYO-1 and 6-ChloroTOTO-1" Presented at 12th Conference on Methods and Applications of Fluorescence Spectroscopy, Imaging and Probes September 2011, Strasbourg France Poster 186
- Harlan FK, Jiang Y, Held PG, Naleway JJ (2010) "High-Throughput Multiple Drug Resistance (MDR) Assays and Systems." Presented at the 50th Annual Meeting of the American Society for Cell Biology in Philadelphia, PA. Section: Cancer Therapeutics 2, Abstract # 643/B1027. link
- Jiang Y, Naleway JJ(2010) "Purification and New Cell Biology Assays Using a Stabilized Luciferase Exhibiting Red Luminescence." Presented at the 50th Annual Meeting of the American Society for Cell Biology in Philadelphia, PA, Section: Imaging Technology 1, Abstract # 388/B537. link
- Jiang Y, Link-Cole RM, Harrington CA, Lindstrom SR, Garred MM, Naleway JJ "New Direct DNA and RNA Labeling Systems." Presented at the 50th Annual Meeting of the American Society for Cell Biology in Philadelphia, PA, Section: Imaging Technology 1, Abstract # 395/B544. link
- Lyons TA, Amouretti XF, Held PG, Naleway JJ (2010) "Development of a Live-Cell Based Reactive Oxygen Species (ROS) Assay for use in High-Content Screening of Drug Candidates Using the BioTek Synergy Mx Microplate Reader." presented at the Society for Biomolecular Sciences 16th Annual Conference in Phoenix, AZ April 11-15, 2010. link
- Coleman DJ, Kuntz DA, Venkatesan M, Cook GM, Williamson SP, Rose DR, Naleway JJ, (2010) "A Long Wavelength Fluorescent Substrate for Continuous Fluorometric Determination of α-Mannosidase Activity: Resorufin α-D-Mannopyranoside." Anal. Biochem. 399:7-12. link
- Naleway JJ, Coleman DJ, Cook GM, Kuntz D, Williamson SP, Sim L, Venkatesan M, Rose DR (2008) "New Resorufin-Based Glycosidase Substrates for Use in Continuous Analysis of Glycosidase Activity in Acidic Organelles." presented at the XXIVth International Carbohydrate Symposium, Oslo, Norway, July, 2008. link
- Naleway JJ, Cook GM, Coleman DJ (2008) " Analysis of Tissue-Specific and Inhibitor Directed Plant Glycan Composition by Fluorescent Labeling with 1,5-EDANS and Combined Gel-Electrophoretic, High-Performance Liquid and Thin-Layer Chromatography Techniques." Abstract B-P023, XXIVth International Carbohydrate Symposium, Oslo, Norway, July, 2008. link
- Coleman DJ, Hawley RM, Cook GM, Naleway JJ (2008) "Cellulase assay as a method of monitoring grape ripening." Experimental Biology Meeting, San Diego, CA April, 2008, Abstract No. 841.2. link
- Coleman, DJ, Guzikowski, AP, Williamson, SP, Naleway, JJ (2008) "Metabolic Lysosomal Enzyme Probes." Experimental Biology Meeting, San Diego, CA April, 2008, Abstract No. 1059.1. link
- Coleman, DJ, McGibney, MT, Cook, GM, Naleway, JJ (2008) "Mammalian Luciferase Decection Vectors and Applications." Experimental Biology Meeting, San Diego, CA April, 2008, Abstract No. 1028.1. link
- Naleway AA, Neff TL, Naleway JJ (2008) "New Positive Selection Systems for lacZ beta-Galactosidase and amp beta-
Lactamase Transgenic Cells." American Society for Cell Biology Meeting, San Francisco, CA Abstract # 496-B445. link
- Coleman DJ, Cook GM, Naleway JJ (2008) "New Codon-Optimized and Stabilized Luciferase from Luciola cruciata Exhibiting Red Luminescence." American Society for Cell Biology Meeting, San Francisco, CA, Abstract # 1280 B490. link
- Coleman DJ, Studler MJ, Naleway JJ (2007) "A long-wavelength fluorescent substrate for continuous fluorometric determination of cellulase activity: resorufin-ß-D-cellobioside.", Anal. Biochem. 371:146-153. link
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