Rose bengal diacetate

Product ID: M0780



Unit SizePriceQuantity 
5mg
$112.20
  • Buy 5 for $89.76 each and save 20%

Availability: In stock


Description

This diacetate derivative of rose bengal exhibits greatly improved membrane permeability, allowing it to accumulate intracellularly where esterase activity releases the active rose bengal photosensitizer.

Rose bengal has been widely used in photodynamic therapy of tumors, to inactivate viruses, gram-positive bacteria and protozoa, and to produce photohemolysis, and induce occlusion of blood vessels in a procedure called photothrombosis. This diacetate analog exhibits greatly improved membrane permeability and cell permeation. Activation with UV light at 561 nm causes singlet oxygen production and photosensitization.

Technical Data
SKU M0780
CAS Number 61738-01-0
Unit Size 5mg
Absorption 313nm
Molecular Formula C₂₄H₈;Cl₄I₄O₇
Molecular Weight 1057.74
Soluble In CH2Cl2, DMSO
Storage Conditions -20C, Desiccated
Notes Upon esterase activation Rose Bengal Product M1277 is released with ABS= 561 nm

References and Citations

References:

  • Bottiroli, G., Croce, A.C., Balzarini, P., Locatelli, D., Baglioni, P., Lo Nostro, P., Monici, M., Pratesi, R.,"Enzyme-assisted cell photosensitization: a proposal for an efficient approach to tumor therapy and diagnosis. The rose bengal fluorogenic substrate." (1997) Photochem. Photobiol. 66, 374-383.
  • Lenard, J., Rabson, A., Vanderoef, R., "Photodynamic inactivation of infectivity of human immunodeficiency virus and other enveloped viruses using hypericin and rose bengal: inhibition of fusion and syncytia formation." (1993) Proc. Natl. Acad. Sci. USA 90:158-162.
  • Dahl, T.A., Midden, W.R., Neckers, D.C., "Comparison of photodynamic action by rose bengal in gram-positive and gram-negative bacteria." (1988) Photochem. Photobiol. 48:607-612.
  • Valenzeno, D.P., Trudgen, J., Hutzenbuhler, A., Milne, M., "Singlet Oxygen involvement in photohemolysis sensitized by mercyanine-540 and rose bengal." (1987) Photochem. Photobiol. 46:985-990.
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