Tetramethylrhodamine, ethyl ester

Product ID: M1722



Unit SizePriceQuantity 
50uL(1mM in DMSO)
$81.86
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  • Tetramethylrhodamine, ethyl ester

Description

Positively charged lipophilic fluorophore with red-orange fluorescence (EX 549; EM 575 nm) that rapidly accumulates in the mitochondria due to the relative negative charge of active mitochondria with respect to the cytosol.

TMRE can be used to monitor spontaneous transient depolarizations of mitochondria (Δψm), sometimes called mitochondrial flickers most commonly attributed to transient activation of the mitochondrial permeability transition pore (PTP).

Technical Data
SKU M1722
Unit Size 50uL(1mM in DMSO)
Alternative Names TMRE
Absorption 549nm
Emission Wavelength 575
Extinction 100
Detection Method Fluorescence
Molecular Formula C₂₆H₂₇ClN₂O₃
Molecular Weight 450.96
Soluble In DMSO, EtOH
Storage Conditions -20C, Desiccated

References and Citations

References:

  • O'Reilly CM, Fogarty KE, Drummond RM, Tuft RA, Walsh JV (2003) "Quantitative Analysis of Spontaneous Mitochondrial Depolarizations." Biophys. J. 85(5): 3350–3357.
  • Collins TJ, Berridge MJ, Lipp P, Bootman MD (2002) "Mitochondria are morphologically and functionally heterogeneous within cells." EMBO J. 21(7): 1616-1627.
  • Duchen MR, Leyssens A, Crompton M (1998) "Transient mitochondrial depolarizations reflect focal sarcoplasmic reticular calcium release in single rat cardiomyocytes." J. Cell Biol. 142(4): 975-988.
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