MarkerGene™ LysoLive™ Lysosomal β-Glucosidase Assay Kit

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1 kit
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This kit utilizes the sensitive substrate GlucGreen™ to monitor beta-glucosidase activity in the lysosomes of live cells.

Lysosomal beta-glucosidase enzyme is currently indicated to be involved in diseases such as Gaucher and Parkinson’s diseases. MarkerGene™ LysoLive™ Lysosomal beta-Glucosidase Assay Kit utilizes a substrate which only becomes fluorescent upon cleavage by the enzyme meaning lysosomes with low beta-Glucosidase (GBA) activity will exhibit reduced staining in a manner proportional to the enzyme activity levels in the cell. 

Important Licensing Information: This product may be covered by one or more United States or International Patents and is subject to our Limited Use Label Licenses. By use of this product, you accept the terms and conditions of all applicable Limited Use Label Licenses. See product information sheet for more details
Corporate entity: Marker Gene Technologies, Inc., Eugene, Oregon, USA
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Publications Using This Product
  • Harlan FK, Lusk JS, Mohr BM, Guzikowski AP, Batchelor RH, Jiang Y, et al. (2016) "Fluorogenic Substrates for Visualizing Acidic Organelle Enzyme Activities." PLoS ONE 11(5): e0156312. doi:10.1371/journal.pone.0156312
  • Jahng JWS, Alsaadi RM, Palanivel R, Song E, Hipolito VEB, Sung HK, Botelho RJ, Russell RC, Sweeney G. (2019) "Iron overload inhibits late stage autophagic flux leading to insulin resistance." EMBO Rep. 20(10):e47911.
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Product Data
Product ID M2775
Unit Size 1 kit
Availability In Stock
Detection Method Fluorescence
Storage Conditions -20C, Protect From Light
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  • Westbroek W, Gustafson AM, Sidransky E. (2011) “Exploring the link between glucocerebrosidase mutations and parkinsonism.” Trends Mol Med. 17(9):485-493.
  • Sidransky E. (2005) “Gaucher disease and parkinsonism.” Mol. Genet. Metab. 84:302-304.
  • Sidransky E (2004) "Gaucher disease: complexity in a “simple” disorder" Molecular genetics and metabolism 83(1-2):6-15.
  • Karageorgos LE, Isaac EL, Brooks DA, Ravenscroft EM, Davey R, Hopwood JJ, Meikle PJ (1997) “Lysosomal biogenesis in lysosomal storage disorders.” Experimental Cell Research 234, 85-97.
  • Neudorfer O, Giladi N, Elstein D, Abrahamov A (1996) "Occurrence of Parkinson’s syndrome in type 1 Gaucher disease." Qjm 691-694.
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